EFFECTS OF PH ON HEAT SENSITIZATION OF MAMMALIAN-CELLS WITH PROCAINE HYDROCHLORIDE

被引：7

作者：

LI, XL ^{[1
]}

WANG, ZH ^{[1
]}

CHU, GL ^{[1
]}

DEWEY, WC ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,RADIAT ONCOL RES LAB,CED-200,SAN FRANCISCO,CA 94143

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1990年 / 18卷 / 04期

关键词：

Heat sensitization; Procaine hydrochloride;

D O I：

10.1016/0360-3016(90)90419-K

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The enhancement of heat killing of CHO cells by treatment with 7 mM procaine HCl increased when cells were treated under alkaline conditions. Below a pH of 6.9, very little heat sensitization was observed; however, as the pH was increased to 7.4 and above, considerable heat sensitization occurred. There were no changes in intracellular pH at the beginning of heating that could be responsible for this phenomenon. © 1990.

引用

页码：933 / 935

页数：3