SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF NOVEL OXADIAZOLE DERIVATIVES

被引：8

作者：

Sahoo, Biswa Mohan ^{[1
]}

Kumar, Ravi B. V. V. ^{[1
]}

Kumari, B. U. B. Prasanna ^{[1
]}

机构：

[1] Roland Inst Pharmaceut Sci, Dept Pharmaceut Chem, Khodasinghi, Berhampur, Orissa, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 02期

关键词：

1,3, 4-oxadiazole; Secondary amines; Synthesis; Anti-inflammatory activity; antibacterial activity;

D O I：

10.13040/IJPSR.0975-8232.2(2).344-50

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

New 5-phenyl-1, 3, 4-oxadiazole-2-thiol derivative was synthesized by the ring closure reactions of benzohydrazides with carbon disulphide in presence of ethanolic KOH followed by substitution with secondary amines at 2nd position. All the newly synthesized compounds were characterized by IR, NMR and LC-MASS spectral data. Most of them were tested for their anti-inflammatory and antibacterial activity.

引用

页码：344 / 350

页数：7

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