A CAROTANE SESQUITERPENE AS A POTENT MODULATOR OF THE MAXI-K CHANNEL FROM ARTHRINIUM-PHAESOSPERMUM

被引：23

作者：

ONDEYKA, JG

BALL, RG

GARCIA, ML

DOMBROWSKI, AW

SABNIS, G

KACZOROWSKI, GJ

ZINK, DL

BILLS, GF

GOETZ, MA

SCHMALHOFER, WA

SINGH, SB

机构：

[1] Merck Research Laboratories, Rahway, NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期

关键词：

D O I：

10.1016/0960-894X(95)00104-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A potent modulator of the Maxi-K channel, isolated from Arthrinium phaeospermum, has been determined to be a carotane sesquiterpene by spectroscopic means. X-ray crystallographic studies demonstrated this compound as being identical to CAF-603, previously discovered as an antifungal agent.

引用

页码：733 / 734

页数：2

共 8 条

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