Formation of a complex of human plasma myeloperoxidase and opsonins

被引：0

作者：

Yankovskii, OY ^{[1
]}

Yablunovskaya, IA ^{[1
]}

Kokryakov, VN ^{[1
]}

Aleshina, GM ^{[1
]}

Govorova, NY ^{[1
]}

Khilazhetdinova, LR ^{[1
]}

Gavrilova, YV ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI,INST EXPTL MED,ST PETERSBURG,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 120卷 / 09期

关键词：

myeloperoxidase; opsonins; protein-protein interaction;

D O I：

10.1007/BF02445030

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Human neutrophil myeloperoxidase adsorbs on immobilized fibronectin or IgG under conditions approaching the physiological ones. Immobilized myeloperoxidase binds liquid-phase plasma fibronectins and thermoaggregated IgG, but not native IgG. Protein-myeloperoxidase interaction is thought to be the mechanism arming phagocytes with this enzyme in the course of phagocytosis of pathogenic microorganism and to be one means of preventing tissue injury by oxidants generated by extracellular myeloperoxidase.

引用

页码：959 / 961

页数：3

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