GROWTH-INHIBITION OF HUMAN PANCREATIC-CANCER CELLS BY CHOLECYSTOKININ RECEPTOR ANTAGONIST IN TISSUE-CULTURE AND IN NUDE-MICE

被引：0

作者：

FUNAKOSHI, A

KONO, A

机构：

来源：

GASTROENTEROLOGIA JAPONICA | 1992年 / 27卷 / 01期

关键词：

CCK; CR-1505; PANCREATIC CANCER CELL LINE;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The Human pancreatic carcinoma cell line KP-1N and its clone KP-1NL which has a high rate of liver metastasis were established. Ki-ras DNA point mutation on the codon 12 was found. The growth of KP-1N was stimulated by a physiological range of concentration (10(-11)-10(-10) M) of cholecystokinin and the increase was inhibited by the addition of a cholecystokinin receptor antagonist (CR 1505). Daily injections of CR 1505 (35 mg/kg) diminished the number of tumor colonies in the liver that were formed after an intrasplenic injection of the highly liver metastatic KP-1NL cells. These results suggest that cholecystokinin antagonists may be useful as growth inhibitors for some pancreatic cancer.

引用

页码：78 / 82

页数：5

共 3 条

[1] CHOLECYSTOKININ ANALOG, JMV-180, GROWTH OF HUMAN PANCREATIC-CANCER
SWIFT, IR
SMITH, JP
DIGESTIVE DISEASES AND SCIENCES, 1994, 39 (05) : 1007 - 1013
[2] ENHANCEMENT OF THE CYTOTOXICITY OF CISPLATIN BY THE CHOLECYSTOKININ ANTAGONIST MK-329 IN A HUMAN PANCREATIC-CANCER CELL-LINE
JAMSHIDIPOUR, R
PINHO, EB
HOM, DK
HOWELL, SB
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1994, 34 (06) : 484 - 490
[3] Receptor-Dependent Growth Inhibition of Human Pancreatic Cancer by 9-cis Retinoic Acid
Vickers S.M.
Sampson L.K.
Ying W.
Phillips J.O.
Journal of Gastrointestinal Surgery, 1997, 1 (2) : 174 - 181

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