Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging

被引：1
作者：
Morbelli, Silvia [1 ,2 ]
Nobili, Flavio [2 ,3 ]
机构：
[1] Univ Genoa, Dept Hlth Sci, Nucl Med Unit, Largo R Benzi 10, I-16132 Genoa, Italy
[2] Univ Genoa, IRCCS, AOU San Martino IST, I-16132 Genoa, Italy
[3] Univ Genoa, Dept Neurosci Ophthalmol Genet & Child Mother Hlt, Clin Neurol, I-16132 Genoa, Italy
来源：
AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2014年 / 4卷 / 03期
关键词：
Brain FDG PET; Alzheimer's disease; cognitive reserve; amyloid PET; mild cognitive impairment;
D O I：
暂无
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Cognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. The present review is focused on the contribution of brain PET in the understanding of the influence of CR on the disassociation between cognition and degree of Alzheimer's disease (AD) pathology. Theories for the explanation CR-related mechanism as well as PET imaging evidence for the existence of CR are described. Moreover functional imaging studies investigating specific networks for CR both in healthy subjects and AD patients are discussed. Finally implications for amyloid PET imaging are presented.
引用
收藏
页码：239 / 247
页数：9
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