Metformin - an old drug revisited

被引:0
作者
Zdrojewicz, Zygmunt [1 ]
Belowska-Bien, Kinga [2 ]
机构
[1] Uniwersytetu Medycznego Wroclawiu, Katedra Klinika Endokrynol Diabetologii Lecze, Wroclaw, Poland
[2] Uniwersytetu Medycznego Wroclawiu, Katedra Zaktad Farrnakol, Wroclaw, Poland
关键词
metformin; prediabetes; cancer;
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Metformin belongs to biguanides, drugs with hypoglycemic activity. The primary indication for its use is type II diabetes, particularly in obese patients in whom non-pharmacological treatment is not effective. Due to its mechanism of action.. metformin is used in other disorders with insulin resistance states, such as polycystic ovary syndrome. The question of applying metformin in pre-diabetic states remains open. The role of metformin in cancer diseases, and in the metabolism of tissues not directly related to energy homeostasis of the organism, is the subject of the recent research,
引用
收藏
页码:43 / 45
页数:3
相关论文
共 25 条
  • [1] Contributions of β-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose
    Abdul-Ghani, MA
    Tripathy, D
    DeFronzo, RA
    [J]. DIABETES CARE, 2006, 29 (05) : 1130 - 1139
  • [2] Bailey C.J., 2004, PRACT DIABETES INT, V21, P115, DOI [10.1002/pdi.606, DOI 10.1002/PDI.606]
  • [3] TRADITIONAL PLANT MEDICINES AS TREATMENTS FOR DIABETES
    BAILEY, CJ
    DAY, C
    [J]. DIABETES CARE, 1989, 12 (08) : 553 - 564
  • [4] Bandurska-Stankiewicz E, 2011, ENDOKRYNOL OTYFOSC Z, V7, P151
  • [5] Bo S, 2011, DIABETES OHES METAB, P1463
  • [6] Free fatty acids in obesity and type 2 diabetes:: defining their role in the development of insulin resistance and β-cell dysfunction
    Boden, G
    Shulman, GI
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2002, 32 : 14 - 23
  • [7] Use of metformin and the risk of ovarian cancer: A case-control analysis
    Bodmer, Michael
    Becker, Claudia
    Meier, Christian
    Jick, Susan S.
    Meier, Christoph R.
    [J]. GYNECOLOGIC ONCOLOGY, 2011, 123 (02) : 200 - 204
  • [8] The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications
    De Leo, V.
    Musacchio, M. C.
    Piomboni, P.
    Di Sabatino, A.
    Morgante, G.
    [J]. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2011, 157 (01) : 63 - 66
  • [9] GARCIA E Y, 1950, J Philipp Med Assoc, V26, P287
  • [10] Obesity and insulin resistance in breast cancer - Chemoprevention strategies with a focus on metformin
    Goodwin, Pamela J.
    Stambolic, Vuk
    [J]. BREAST, 2011, 20 : S31 - S35