Redox-regulation of protein import into chloroplasts and mitochondria Similarities and differences

被引:15
作者
Stengel, Anna
Benz, J. Philipp
Soll, Juergen
Boelter, Bettina [1 ]
机构
[1] Ludwig Maximilians Univ Munchen, Munich Ctr Integrated Prot Sci CiPSM, Munich, Germany
关键词
protein import; chloroplasts; mitochondria; redox-regulation; disulfide bridges; NADP(H); Toc; Tic; Tom;
D O I
10.4161/psb.5.2.10525
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Redox signals play important roles in many developmental and metabolic processes, in particular in chloroplasts and mitochondria. Furthermore, redox reactions are crucial for protein folding via the formation of inter-or intramolecular disulfide bridges. Recently, redox signals were described to be additionally involved in regulation of protein import: in mitochondria, a disulfide relay system mediates retention of cystein-rich proteins in the intermembrane space by oxidizing them. Two essential proteins, the redox-activated receptor Mia40 and the sulfhydryl oxidase Erv1 participate in this pathway. In chloroplasts, it becomes apparent that protein import is affected by redox signals on both the outer and inner envelope: at the level of the Toc complex (translocon at the outer envelope of chloroplasts), the formation/ reduction of disulfide bridges between the Toc components has a strong influence on import yield. Moreover, the stromal metabolic redox state seems to be sensed by the Tic complex (translocon at the inner envelope of chloroplasts) that is able to adjust translocation efficiency of a subgroup of redox-related preproteins accordingly. This review summarizes the current knowledge of these redox-regulatory pathways and focuses on similarities and differences between chloroplasts and mitochondria.
引用
收藏
页码:105 / 109
页数:5
相关论文
共 42 条
  • [21] Tic32, an essential component in chloroplast biogenesis
    Hörmann, F
    Küchler, M
    Sveshnikov, D
    Oppermann, U
    Li, Y
    Soll, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (33) : 34756 - 34762
  • [22] Targeting of nucleus-encoded proteins to chloroplasts in plants
    Jarvis, Paul
    [J]. NEW PHYTOLOGIST, 2008, 179 (02) : 257 - 285
  • [23] Protein import into chloroplasts involves redox-regulated proteins
    Küchler, M
    Decker, S
    Hörmann, F
    Soll, J
    Heins, L
    [J]. EMBO JOURNAL, 2002, 21 (22) : 6136 - 6145
  • [24] An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins
    Lange, H
    Lisowsky, T
    Gerber, J
    Mühlenhoff, U
    Kispal, G
    Lill, R
    [J]. EMBO REPORTS, 2001, 2 (08) : 715 - 720
  • [25] Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase
    Lee, JE
    Hofhaus, G
    Lisowsky, T
    [J]. FEBS LETTERS, 2000, 477 (1-2) : 62 - 66
  • [26] Origin, evolution and genetic effects of nuclear insertions of organelle DNA
    Leister, D
    [J]. TRENDS IN GENETICS, 2005, 21 (12) : 655 - 663
  • [27] Margulis L., 1970, ORIGIN EUKARYOTIC CE
  • [28] McCarthy AA, 2000, NAT STRUCT BIOL, V7, P196
  • [29] A disulfide relay system in the intermembrane space of mitochondria that mediates protein import
    Mesecke, N
    Terziyska, N
    Kozany, C
    Baumann, F
    Neupert, W
    Hell, K
    Herrmann, JM
    [J]. CELL, 2005, 121 (07) : 1059 - 1069
  • [30] The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40
    Mesecke, Nikola
    Bihlmaier, Karl
    Grumbt, Barbara
    Longen, Sebastian
    Terziyska, Nadia
    Hell, Kai
    Herrmann, Johannes M.
    [J]. EMBO REPORTS, 2008, 9 (11) : 1107 - 1113