EFFECT OF LONG-CHAIN FATTY-ACIDS ON LOW-DENSITY-LIPOPROTEIN-CHOLESTEROL METABOLISM

被引：21
作者：
WOOLLETT, LA
DIETSCHY, JM
机构：
[1] Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX
[2] Univ. Texas Southwestern Med. Ctr., Department of Internal Medicine, Dallas, TX 75235-8887
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1994年 / 60卷 / 06期
关键词：
LOW-DENSITY LIPOPROTEIN; LONG-CHAIN FATTY ACIDS; CHOLESTEROL; LIVER; CHOLESTERYL ESTERS;
D O I：
10.1093/ajcn/60.6.991S
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The concentration of cholesterol in the low-density-lipoprotein (LDL) fraction of plasma is one of the major risk factors for coronary heart disease. Steady-state concentrations of LDL cholesterol in the plasma are determined primarily by the production rate and the rate of removal of LDL cholesterol from the circulation by receptor-dependent transport. The magnitude of these two processes is affected by the type of fatty acid in the diet. Saturated fatty acids with 14 and 16 carbon atoms suppress receptor-dependent LDL-cholesterol transport into the liver, increase the LDL-cholesterol production rate, and raise the plasma LDL-cholesterol concentration. The 9-cis 18:1 fatty acid restores receptor activity, lowers the production rate, and decreases the plasma LDL-cholesterol concentration. In contrast with these fatty acids, the 18:0 and 9-trans 18:1 fatty acids are biologically inactive and so do not change the circulating LDL-cholesterol concentration.
引用
收藏
页码：991S / 996S
页数：6
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