NATURALLY-OCCURRING PROTEIN-KINASE-C INHIBITORS .2. ISOLATION OF OLIGOMERIC STILBENES FROM CARAGANA-SINICA

被引：47

作者：

KULANTHAIVEL, P ^{[1
]}

JANZEN, WP ^{[1
]}

BALLAS, LM ^{[1
]}

JIANG, JB ^{[1
]}

HU, CQ ^{[1
]}

DARGES, JW ^{[1
]}

SELDIN, JC ^{[1
]}

COFIELD, DJ ^{[1
]}

ADAMS, LM ^{[1
]}

机构：

[1] SHANGHAI MED UNIV,SCH PHARM,DEPT NAT DRUGS,SHANGHAI 200032,PEOPLES R CHINA

来源：

PLANTA MEDICA | 1995年 / 61卷 / 01期

关键词：

CARAGANA SINICA (BUCHOZ) REHD; LEGUMINOSAE; (+)-ALPHA-VINIFERIN; MIYABENOL C; KOBOPHENOL A; OLIGOMERIC STILBENES; PROTEIN KINASE C ACTIVITY;

D O I：

10.1055/s-2006-957996

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 mu M) and free radical release in whole blood (47 mu M), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.

引用

页码：41 / 44

页数：4

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