THE METABOLISM OF 3-METHYLHEPTANE IN MALE 344 FISCHER RATS

被引：5
|
作者：
SERVE, MP [1 ]
BOMBICK, DD [1 ]
CLEMENS, JM [1 ]
MCDONALD, GA [1 ]
HIXSON, CJ [1 ]
MATTIE, DR [1 ]
机构：
[1] ARMSTRONG AEROSP MED RES LABS, WRIGHT PATTERSON AFB, OH 45433 USA
来源：
CHEMOSPHERE | 1993年 / 26卷 / 09期
关键词：
D O I：
10.1016/0045-6535(93)90111-H
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
3-Methylheptane (3-MH), a component of fuels and solvents, is found widely distributed in the environment. Male 344 Fischer rats, dosed by gavage with 3-MH yielded the following urinary metabolites, identified by gas chromatography and mass spectrometry: 3,5-diethyl-2,3-dihydrofuran, 3-ethyl-6-methyl-2,3-dihydropyran, 3-methyl-heptanol, 3-methyl-2-heptanol, 5-methyl-2-heptanol, 2-n-butyl-1,3-butanediol, 2-ethyl-1,3-hexanediol, beta-methyl-delta-enantholactone, 3-methyl-3,4-heptanediol, 3-methyl-3,4-heptanediol, 3-methyl-3,5-heptanediol, 2-ethyl-1,4-hexanediol, 8-methyl-delta-enantholactone, 5-methyl-2,5-heptanediol, 2-ethyl-1,5-hexanediol and 2-ethylhexanoic acid. Pathological evalution of the proximal tubules of the rat's kidneys rated 3-MH as a moderate inducer of the the hyaline droplet nephropathy induced by branched chain hydrocarbons.
引用
收藏
页码：1667 / 1677
页数：11
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