THE METABOLISM OF 3-METHYLHEPTANE IN MALE 344 FISCHER RATS

被引：5

作者：

SERVE, MP ^{[1
]}

BOMBICK, DD ^{[1
]}

CLEMENS, JM ^{[1
]}

MCDONALD, GA ^{[1
]}

HIXSON, CJ ^{[1
]}

MATTIE, DR ^{[1
]}

机构：

[1] ARMSTRONG AEROSP MED RES LABS, WRIGHT PATTERSON AFB, OH 45433 USA

来源：

CHEMOSPHERE | 1993年 / 26卷 / 09期

关键词：

D O I：

10.1016/0045-6535(93)90111-H

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

3-Methylheptane (3-MH), a component of fuels and solvents, is found widely distributed in the environment. Male 344 Fischer rats, dosed by gavage with 3-MH yielded the following urinary metabolites, identified by gas chromatography and mass spectrometry: 3,5-diethyl-2,3-dihydrofuran, 3-ethyl-6-methyl-2,3-dihydropyran, 3-methyl-heptanol, 3-methyl-2-heptanol, 5-methyl-2-heptanol, 2-n-butyl-1,3-butanediol, 2-ethyl-1,3-hexanediol, beta-methyl-delta-enantholactone, 3-methyl-3,4-heptanediol, 3-methyl-3,4-heptanediol, 3-methyl-3,5-heptanediol, 2-ethyl-1,4-hexanediol, 8-methyl-delta-enantholactone, 5-methyl-2,5-heptanediol, 2-ethyl-1,5-hexanediol and 2-ethylhexanoic acid. Pathological evalution of the proximal tubules of the rat's kidneys rated 3-MH as a moderate inducer of the the hyaline droplet nephropathy induced by branched chain hydrocarbons.

引用

页码：1667 / 1677

页数：11

共 41 条

[1]

ALI MF, 1986, ARAB J SCI ENG, V11, P251

[2]

AMES B, 1990, SCIENCE, V250, P743

[3]

ASANO A, 1988, Patent No. 1141998

[4] PHOTOCHEMICAL REACTIONS .59. ON MECHANISM OF PHOTODECARBONYLATION OF BETA,GAMMA-UNSATURATED ALDEHYDES [J].

BAGGIOLI.E ;

HAMLOW, HP ;

SCHAFFNE.K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (16) :4906-&

[5] IDENTIFICATION OF VOLATILE METABOLITES OF INHALED NORMAL-HEPTANE IN RAT URINE [J].

BAHIMA, J ;

CERT, A ;

MENENDEZGALLEGO, M .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 76 (03) :473-482

[6]

BEATI E, 1940, ANN CHIM APPL, V30, P21

[7] CHARACTERISTICS OF CHEMICAL-BINDING TO ALPHA-2U-GLOBULIN INVITRO - EVALUATING STRUCTURE-ACTIVITY-RELATIONSHIPS [J].

BORGHOFF, SJ ;

MILLER, AB ;

BOWEN, JP ;

SWENBERG, JA .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 107 (02) :228-238

[8]

BOSTWICK CO, 1953, Patent No. 2643262

[9] SOLVOMERCURATION-DEMERCURATION .8. OXYMERCURATION-DEMERCURATION OF METHOXY-SUBSTITUTED, HYDROXY-SUBSTITUTED, AND ACETOXY-SUBSTITUTED ALKENES [J].

BROWN, HC ;

LYNCH, GJ .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (03) :531-538

[10] LOCALIZATION OF ALPHA-2U-GLOBULIN WITHIN PROTEIN DROPLETS OF MALE-RAT KIDNEY - IMMUNOHISTOCHEMISTRY USING PERFUSION-FIXED, GMA-EMBEDDED TISSUE-SECTIONS [J].

BURNETT, VL ;

SHORT, BG ;

SWENBERG, JA .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1989, 37 (06) :813-818

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