CONVENIENT SYNTHESIS OF 2,4-CYCLOHEXADIEN-1-ONES BY REGIOSELECTIVE METHYLTHIOMETHYLATION OF PHENOLS

被引：0

作者：

KATAYAMA, S ^{[1
]}

WATANABE, T ^{[1
]}

YAMAUCHI, M ^{[1
]}

机构：

[1] JOSAI UNIV, FAC PHARMACEUT SCI, SAKADO, SAITAMA 35002, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 03期

关键词：

2,4-CYCLOHEXADIEN-1-ONE; S; S-DIMETHYLSUCCINIMIDOSULFONIUM CHLORIDE; COREY-KIM REAGENT; REGIOSELECTIVE METHYLTHIOMETHYLATION; REGIOSELECTIVITY; REGIOISOMER;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of a variety of 2,4-cyclohexadien-1-ones 3-7 is described. Reaction of various phenols 2 having appropriate substituents with an excess of SS-dimethylsuccinimidosulfonium chloride (Corey-Kim reagent, 1) in the presence of triethylamine proceeded with regioselective methylthiomethylation to give methylthiomethyl, bis(methylthiomethyl), or tris(methylthiomethyl)-2,4-cyclohexadien-1-ones 3-7 in satisfactory yields.

引用

页码：439 / 444

页数：6

共 50 条

[41] A convenient synthesis of 3-phenylthio-azetidin-2-ones
Bari, SS
Sharma, AK
Sethi, MK
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1998, 37 (11): : 1114 - 1119
[42] SYNTHESIS OF SOME 2,4-BENZODIAZEPIN-1-ONES, POTENT CNS AGENTS
GOLIK, U
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (05) : 903 - 908
[43] SYNTHESIS OF SOME 2,4-BENZODIAZEPIN-1-ONES, POTENT CNS AGENTS
GOLIK, U
TETRAHEDRON LETTERS, 1975, (16) : 1327 - 1328
[44] SYNTHESIS OF 4-HYDROXY-2,5-CYCLOHEXADIEN-1-ONES WITH ISOPRENOID SUBSTITUENTS OF DIFFERENT STRUCTURE
TUTORSKAYA, OO
MIROPOLSKAYA, MA
SAMOKHVALOV, GI
ZHURNAL ORGANICHESKOI KHIMII, 1991, 27 (07): : 1423 - 1428
[45] A New Convenient Synthesis of 2,4-Disubstituted-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-ones
Shawali, Ahmad S.
Hassaneen, Hamdi M.
Shurrab, Nabil Kh.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 45 (06) : 1825 - 1829
[46] A CONVENIENT SYNTHESIS OF 3-(1,3-ALKADIENYL)-2-CYCLOALKEN-1-ONES
LU, XY
GUO, C
MA, D
SYNLETT, 1990, (06) : 357 - 358
[47] Convenient synthesis of 2,4-disubstituted pyrido[2,3-d]pyrimidines via regioselective palladium-catalyzed reactions
Riadi, Yassine
Massip, Stephane
Leger, Jean-Michel
Jarry, Christian
Lazar, Said
Guillaumet, Gerald
TETRAHEDRON, 2012, 68 (25) : 5018 - 5024
[48] Convenient and Efficient Synthesis of 2,4-Dideoxy-levoglucosan
Ermolenko, Mikhail S.
SYNTHETIC COMMUNICATIONS, 2013, 43 (21) : 2841 - 2845
[49] A CONVENIENT SYNTHESIS OF 2-BROMO-4-HYDROXY-2-CYCLOPENTEN-1-ONES AND 3-BROMO-4-HYDROXY-2-CYCLOPENTEN-1-ONES
DAURIA, M
DONOFRIO, F
PIANCATELLI, G
SCETTRI, A
GAZZETTA CHIMICA ITALIANA, 1986, 116 (04): : 173 - 175
[50] THE 1ST INTERMOLECULAR 2+2 PHOTOCYCLOADDITIONS OF 2,5-CYCLOHEXADIEN-1-ONES TO ALKENES
SCHULTZ, AG
TAVERAS, AG
TETRAHEDRON LETTERS, 1988, 29 (52) : 6881 - 6884

← 1 2 3 4 5 →