CONVENIENT SYNTHESIS OF 2,4-CYCLOHEXADIEN-1-ONES BY REGIOSELECTIVE METHYLTHIOMETHYLATION OF PHENOLS

被引：0

作者：

KATAYAMA, S ^{[1
]}

WATANABE, T ^{[1
]}

YAMAUCHI, M ^{[1
]}

机构：

[1] JOSAI UNIV, FAC PHARMACEUT SCI, SAKADO, SAITAMA 35002, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1993年 / 41卷 / 03期

关键词：

2,4-CYCLOHEXADIEN-1-ONE; S; S-DIMETHYLSUCCINIMIDOSULFONIUM CHLORIDE; COREY-KIM REAGENT; REGIOSELECTIVE METHYLTHIOMETHYLATION; REGIOSELECTIVITY; REGIOISOMER;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of a variety of 2,4-cyclohexadien-1-ones 3-7 is described. Reaction of various phenols 2 having appropriate substituents with an excess of SS-dimethylsuccinimidosulfonium chloride (Corey-Kim reagent, 1) in the presence of triethylamine proceeded with regioselective methylthiomethylation to give methylthiomethyl, bis(methylthiomethyl), or tris(methylthiomethyl)-2,4-cyclohexadien-1-ones 3-7 in satisfactory yields.

引用

页码：439 / 444

页数：6

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