USE OF BINDING-ENERGY IN CATALYSIS ANALYZED BY MUTAGENESIS OF THE TYROSYL-TRANSFER RNA-SYNTHETASE

被引：122
作者：
WELLS, TNC [1 ]
FERSHT, AR [1 ]
机构：
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND
来源：
BIOCHEMISTRY | 1986年 / 25卷 / 08期
关键词：
D O I：
10.1021/bi00356a007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1881 / 1886
页数：6
相关论文
共 19 条
  • [1] THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS)
    CARTER, PJ
    WINTER, G
    WILKINSON, AJ
    FERSHT, AR
    [J]. CELL, 1984, 38 (03) : 835 - 840
  • [2] FERSHT A, 1985, ENZYME STRUCTURE MEC, pCH12
  • [3] FINE-STRUCTURE ACTIVITY ANALYSIS OF MUTATIONS AT POSITION 51 OF TYROSYL-TRANSFER RNA-SYNTHETASE
    FERSHT, AR
    WILKINSON, AJ
    CARTER, P
    WINTER, G
    [J]. BIOCHEMISTRY, 1985, 24 (21) : 5858 - 5861
  • [4] HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING
    FERSHT, AR
    SHI, JP
    KNILLJONES, J
    LOWE, DM
    WILKINSON, AJ
    BLOW, DM
    BRICK, P
    CARTER, P
    WAYE, MMY
    WINTER, G
    [J]. NATURE, 1985, 314 (6008) : 235 - 238
  • [5] LIGAND-BINDING AND ENZYMIC CATALYSIS COUPLED THROUGH SUBUNITS IN TYROSYL-TRANSFER-RNA SYNTHETASE
    FERSHT, AR
    MULVEY, RS
    KOCH, GLE
    [J]. BIOCHEMISTRY, 1975, 14 (01) : 13 - 18
  • [6] CATALYSIS, BINDING AND ENZYME-SUBSTRATE COMPLEMENTARITY
    FERSHT, AR
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1974, 187 (1089): : 397 - 407
  • [7] ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING
    FERSHT, AR
    SHI, JP
    WILKINSON, AJ
    BLOW, DM
    CARTER, P
    WAYE, MMY
    WINTER, GP
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07): : 467 - 473
  • [8] JENCKS WP, 1975, ADV ENZYMOL RAMB, V43, P219
  • [9] Jencks WP, 1969, CATALYSIS CHEM ENZYM
  • [10] THE INTRACELLULAR CONCENTRATION OF PYROPHOSPHATE IN THE BATCH CULTURE OF ESCHERICHIA-COLI
    KUKKO, E
    HEINONEN, J
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 127 (02): : 347 - 349
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