STAUROSPORINE BOTH ACTIVATES AND INHIBITS SERINE THREONINE KINASES IN HUMAN PLATELETS

被引：38

作者：

KOCHER, M ^{[1
]}

CLEMETSON, KJ ^{[1
]}

机构：

[1] UNIV BERN,THEODOR KOCHER INST,FREIESTR 1,POB 99,CH-3012 BERN,SWITZERLAND

来源：

BIOCHEMICAL JOURNAL | 1991年 / 275卷

关键词：

D O I：

10.1042/bj2750301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of staurosporine on a selection of protein kinases were investigated with thrombin-stimulated and control human blood platelets. The results demonstrate that staurosporine (1-mu-M) can lead to activation of certain protein kinases in intact platelets and has a general inhibitory effect on the renaturable protein kinases in vitro. New candidates for protein kinases involved in signal transduction are identified.

引用

页码：301 / 306

页数：6

共 32 条

[1] INOSITOL PHOSPHATES AND CELL SIGNALING [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1989, 341 (6239) :197-205

[2] A YEAST GENE THAT IS ESSENTIAL FOR RELEASE FROM GLUCOSE REPRESSION ENCODES A PROTEIN-KINASE [J].

CELENZA, JL ;

CARLSON, M .

SCIENCE, 1986, 233 (4769) :1175-1180

[3] STAUROSPORINE INHIBITS THE RESPIRATORY BURST AND INDUCES EXOCYTOSIS IN HUMAN-NEUTROPHILS [J].

DEWALD, B ;

THELEN, M ;

WYMANN, MP ;

BAGGIOLINI, M .

BIOCHEMICAL JOURNAL, 1989, 264 (03) :879-884

[4] TYROSINE-SPECIFIC PROTEIN-PHOSPHORYLATION IS REGULATED BY GLYCOPROTEIN-IIB-IIIA IN PLATELETS [J].

FERRELL, JE ;

MARTIN, GS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2234-2238

[5]

FERRELL JE, 1989, J BIOL CHEM, V264, P20723

[6] PLATELET TYROSINE-SPECIFIC PROTEIN-PHOSPHORYLATION IS REGULATED BY THROMBIN [J].

FERRELL, JE ;

MARTIN, GS .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) :3603-3610

[7]

FOX JEB, 1989, J BIOL CHEM, V264, P9520

[8]

FRIEDMAN BA, 1990, CANCER RES, V50, P533

[9] BLOOD-PLATELETS EXPRESS HIGH-LEVELS OF THE PP60C-SRC-SPECIFIC TYROSINE KINASE-ACTIVITY [J].

GOLDEN, A ;

NEMETH, SP ;

BRUGGE, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :852-856

[10] STAUROSPORINE-INDUCED NEURITE OUTGROWTH IN PC12H CELLS [J].

HASHIMOTO, S ;

HAGINO, A .

EXPERIMENTAL CELL RESEARCH, 1989, 184 (02) :351-359

← 1 2 3 4 →