CEREBRAL DOPPLER-RECORDINGS IN NEWBORNS AT RISK ARE NOT OF PROGNOSTIC VALUE

Problem: The prognostic value of cerebral doppler for the neonatal and the developmental prognosis was studied. Methods: A prospective longitudinal Study on 175 newborns at risk was performed. The blood flow velocities were recorded transcranially in the middle cerebral, posterior cerebral and internal carotid artery on day 1, 3-5 and 8-10 of life. Neonatal mortality and cerebral sonography gave the criteria for neonatal prognosis. Developmental prognosis was determined at a corrected age of 9 months by neurological examination and Griffth's test. Results: In 60 neonates abnormal flow velocities were obtained at least at one recording. Ultrasound revealed cerebral hemorrhage in 20, hypoxic-ischemic encephalopathy in 5 children. 14 infants died during the neonatal period, 5 in the following months. Premature babies with birth weights below 1501 g and abnormal flow velocities presented more cerebral hemorrhages and deaths than those with normal flow velocities. At the age of 9 months a slight handicap was observed in 10, a severe handicap in 6 of the surviving 156 infants. The majority of infants with abnormal neonatal dopper-recording had a normal neurodevelopmental status. Consequence: Cerebral doppler seems to be of little value to determine the prognosis of newborns at risk.