PROBING HISTIDINE SUBSTRATE INTERACTIONS IN TYROSYL-TRANSFER RNA-SYNTHETASE USING ASPARAGINE AND GLUTAMINE REPLACEMENTS

被引:93
作者
LOWE, DM
FERSHT, AR
WILKINSON, AJ
CARTER, P
WINTER, G
机构
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND
[2] MRC,MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
关键词
D O I
10.1021/bi00340a022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:5106 / 5109
页数:4
相关论文
共 12 条
[1]   CONSERVED CYSTEINE AND HISTIDINE-RESIDUES IN THE STRUCTURES OF THE TYROSYL AND METHIONYL-TRANSFER RNA-SYNTHETASES [J].
BARKER, DG ;
WINTER, G .
FEBS LETTERS, 1982, 145 (02) :191-193
[2]   PURIFICATION AND PHYSICAL CHARACTERIZATION OF TYROSYL RIBONUCLEIC ACID SYNTHETASES FROM ESCHERICHIA COLI AND BACILLUS SUBTILIS [J].
CALENDAR, R ;
BERG, P .
BIOCHEMISTRY, 1966, 5 (05) :1681-&
[3]   THE USE OF DOUBLE MUTANTS TO DETECT STRUCTURAL-CHANGES IN THE ACTIVE-SITE OF THE TYROSYL-TRANSFER RNA-SYNTHETASE (BACILLUS-STEAROTHERMOPHILUS) [J].
CARTER, PJ ;
WINTER, G ;
WILKINSON, AJ ;
FERSHT, AR .
CELL, 1984, 38 (03) :835-840
[4]   HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
KNILLJONES, J ;
LOWE, DM ;
WILKINSON, AJ ;
BLOW, DM ;
BRICK, P ;
CARTER, P ;
WAYE, MMY ;
WINTER, G .
NATURE, 1985, 314 (6008) :235-238
[5]   DEMONSTRATION OF 2 REACTION PATHWAYS FOR AMINOACYLATION OF TRANSFER-RNA - APPLICATION OF PULSED QUENCHED FLOW TECHNIQUE [J].
FERSHT, AR ;
JAKES, R .
BIOCHEMISTRY, 1975, 14 (15) :3350-3356
[6]   LIGAND-BINDING AND ENZYMIC CATALYSIS COUPLED THROUGH SUBUNITS IN TYROSYL-TRANSFER-RNA SYNTHETASE [J].
FERSHT, AR ;
MULVEY, RS ;
KOCH, GLE .
BIOCHEMISTRY, 1975, 14 (01) :13-18
[7]   ANALYSIS OF ENZYME STRUCTURE AND ACTIVITY BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
WILKINSON, AJ ;
BLOW, DM ;
CARTER, P ;
WAYE, MMY ;
WINTER, GP .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (07) :467-473
[8]   TYROSYL-TRANSFER-RNA SYNTHETASE FROM ESCHERICHIA-COLI - STOICHIOMETRY OF LIGAND-BINDING AND HALF-OF-SITES REACTIVITY IN AMINOACYLATION [J].
JAKES, R ;
FERSHT, AR .
BIOCHEMISTRY, 1975, 14 (15) :3344-3350
[9]   AMINO-ACID ACTIVATION IN CRYSTALLINE TYROSYL-TRANSFER RNA-SYNTHETASE FROM BACILLUS-STEAROTHERMOPHILUS [J].
RUBIN, J ;
BLOW, DM .
JOURNAL OF MOLECULAR BIOLOGY, 1981, 145 (03) :489-500
[10]   SITE-DIRECTED MUTAGENESIS AS A PROBE OF ENZYME STRUCTURE AND CATALYSIS - TYROSYL-TRANSFER RNA-SYNTHETASE CYSTEINE-35 TO GLYCINE-35 MUTATION [J].
WILKINSON, AJ ;
FERSHT, AR ;
BLOW, DM ;
WINTER, G .
BIOCHEMISTRY, 1983, 22 (15) :3581-3586