Genetics of uveal melanoma

被引：0
作者：
Mensink, Hanneke W. [2 ]
Paridaens, Dion [2 ]
de Klein, Annelies [1 ]
机构：
[1] Erasmus MC, Dept Clin Genet, POB 2040, NL-3000 CA Rotterdam, Netherlands
[2] Rotterdam Eye Hosp, NL-3000 LM Rotterdam, Netherlands
来源：
EXPERT REVIEW OF OPHTHALMOLOGY | 2009年 / 4卷 / 06期
关键词：
chromosomal aberration; expression profiling; genetic technique; prognostic factor; uveal melanoma;
D O I：
10.1586/EOP.09.53
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
In this review, we discuss the genetic features of uveal melanoma and the different available genetic and genomic tests. Despite improvements in diagnosis and treatment of this intraocular tumor, there has not been a change in survival in the past few decades. Insights into the molecular changes in uveal melanoma have provided us with the opportunity to assess the risk of metastatic disease for individual patients. There are few treatments available for metastasized uveal melanoma and, in a relatively short time-frame, patients with this condition die because of this metastasis. The focus of research may need to shift towards adjuvant therapies for high-risk uveal melanomas.
引用
收藏
页码：607 / 616
页数：10
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