EFFECTS OF CHRONIC IRON-DEFICIENCY ANEMIA ON BRAIN METABOLISM

被引:11
作者
TANAKA, M
KARIYA, F
KAIHATSU, K
NAKAMURA, K
ASAKURA, T
KURODA, Y
OHIRA, Y
机构
[1] NATL INST FITNESS & SPORTS,DEPT PHYSIOL & BIOMECH,KANOYA 89123,JAPAN
[2] KAGOSHIMA IMMACULATE HEART UNIV,SCH NURSING,SENDAI,MIYAGI 895,JAPAN
[3] KAGOSHIMA UNIV,FAC MED,DEPT NEUROSURG,KAGOSHIMA 890,JAPAN
[4] JAPAN WOMENS COLL PHYS EDUC,DEPT SPORTS MED,TOKYO 157,JAPAN
关键词
IRON DEFICIENCY ANEMIA; BRAIN METABOLISM; PHOSPHORUS COMPOUNDS; ENZYMES;
D O I
10.2170/jjphysiol.45.257
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The effects of chronic iron deficiency anemia on brain (cortex) metabolism were estimated by P-31-nuclear magnetic resonance spectroscopy and biochemical analyses in male Wistar rats. Iron deficiency anemia was induced by supplying diet containing either similar to 2 or similar to 6 ppm Fe. Control diet was supplemented with 100 ppm Fe as ferric citrate. After 8-9 weeks, blood hemoglobin levels were approximately 13, 5, and 3 g/100 mi in the 100 ppm, 6 ppm, and 2 ppm Fe group, respectively. The blood lactate levels at rest in these groups were approximately 3, 5, and 6 mM. The blood glucose concentration also tended to be elevated in iron-deficient rats. The high-energy phosphate contents in brain were not affected by iron deficiency. The activities of succinate dehydrogenase and cytochrome oxidase per unit protein in the 2 ppm Fe group were significantly less than in the 100ppm Fe group, but those activities were not significantly affected by feeding diet with 6ppm Fe. The activities of lactate dehydrogenase in iron-deficient group tended to be elevated but not significantly. The activities of non-iron containing mitochondrial enzymes, citrate synthase and beta-hydroxyacyl CoA dehydrogenase, were unchanged. It is suggested that the brain has a higher tolerance to iron deficiency than skeletal muscle in terms of the metabolic characteristics, although this may be associated with a lower level of neural activity.
引用
收藏
页码:257 / 263
页数:7
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