Bioactive guanidine alkaloids from Pterogyne nitens

被引：28
作者：
Bolzani, VDS
Gunatilaka, AAL
Kingston, DGI
机构：
[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061
[2] UNIV ESTADUAL PAULISTA,INST QUIM,BR-14800 ARARAQUARA,SP,BRAZIL
来源：
JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 11期
关键词：
D O I：
10.1021/np50125a006
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioactivity-guided fractionation of a methanolic CHCl3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine (2) and three new guanidine alkaloids, nitensidines A (3), B (4), and C (5), all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC12 = 9.3 - 20.0 mu g/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B-1 cells (IC50 = 8.5 - 13.0 mu g/ml).
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页码：1683 / 1688
页数：6
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