ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO ALDEHYDES CATALYZED BY PYRIDINEOXAZOLINEALCOHOLS

被引：42
|
作者：
MACEDO, E [1 ]
MOBERG, C [1 ]
机构：
[1] ROYAL INST TECHNOL,DEPT CHEM,S-10044 STOCKHOLM,SWEDEN
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 02期
基金：
瑞典研究理事会;
关键词：
D O I：
10.1016/0957-4166(95)00039-R
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Chiral 2-pyridylcarbinols carrying chiral oxazolyl substituents in the 6-position of the pyridine ring catalyze the enantioselective addition of diethylzinc to aromatic aldehydes. The absolute configuration of the product alcohol is determined by the configuration at the stereogenic center bearing the alcohol group, the effect of the oxazoline ring being to increase the stereoselectivity. Attempts to use methyl ether derivatives of the same ligands in the rhodium-catalyzed hydrosilylation of acetophenone did not result in any observed enantioselectivity.
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页码：549 / 558
页数：10
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