COMPARISON OF HEPATIC RESECTION AND TRANSPLANTATION IN THE TREATMENT OF LIVER-CANCER

被引:21
作者
BISMUTH, H
CHICHE, L
机构
[1] Hepatobiliary Surgery and Liver Transplant Research Unit, South Paris University Faculty of Medicine, HǒLpital Paul Brousse, Villejuif
来源
SEMINARS IN SURGICAL ONCOLOGY | 1993年 / 9卷 / 04期
关键词
HEPATOCELLULAR CARCINOMA; LIVER RESECTION;
D O I
10.1002/ssu.2980090412
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
One hundred twenty cirrhotic patients underwent hepatic resection (n = 60) or transplantation (n = 60) for hepatocellular carcinoma. Overall 3-year survival and survival without recurrence were 50% and 23% in the resection group compared to 47% and 44% in the transplantation group. Several characteristics of the tumors have been studied in order to determine prognostic factors in both groups. Thus, results for 3-year survival without recurrence following transplantation in patients with tumors < 3 cm/one or two nodules (83%) were superior to those following transplantation in patients with tumors larger than 3 cm or three or more nodules (37%) (P < 0.02) and to those following resection (10%). Thus, for patients with small tumors, until now the best candidates for resection, transplantation appears to have significantly better results. Conversely, for larger lesions, with three or more nodules, transplantation, in view of the critical donor situation, is probably not indicated. (C) 1993 Wiley-Liss, Inc.
引用
收藏
页码:341 / 345
页数:5
相关论文
共 20 条
[1]  
Okuda K, Hepatocellular carcinoma: Recent progress, Hepatology, 15, pp. 948-963, (1992)
[2]  
Ann Surg, 211, pp. 277-287, (1990)
[3]  
Bismuth H, Houssin D, Ornowski J, Merrigi F, Liver resections in cirrhotic patients: A Western experience, World J Surg, 10, pp. 311-317, (1986)
[4]  
Bismuth H, Morino M, Sherlock D, Et al., Primary treatment of hepatocellular carcinoma by arterial chemoembolisation, Am J Surg, 163, pp. 387-394, (1992)
[5]  
Shiina S, Tagawa K, Unuma T, Et al., Percutaneous ethanol injection therapy for hepatocellular carcinoma: A histopathologic study, Cancer, 68, pp. 1524-1530, (1991)
[6]  
Ohto M, Ebara M, Yoshikawa M, Okuda K, Radiation therapy and percutaneous ethanol injection for liver neoplasms analysis of 79 cases, Radiology, 177, pp. 156-158, (1990)
[7]  
Bismuth H, Houssin D, Castaing D, Major and minor segmentectomies “Reglees” in liver surgery, World J Surg, 6, pp. 10-24, (1982)
[8]  
Castaing D, Garden OJ, Bismuth H, Segmental liver resection using ultrasound‐guided selective portal venous occlusion, Ann Surg, 201, pp. 20-23, (1989)
[9]  
Bismuth H, Liver transplantation: The Paul Brousse experience, Transplant Proc, 20, pp. 486-489, (1988)
[10]  
Nakashima T, Okuda K, Kojiro M, Pathology of hepatocellular carcinoma in Japan: 232 consecutive cases autopsied in 10 years, Cancer, 51, pp. 863-877, (1983)