SALMONELLA MUTAGENICITY TESTS .5. RESULTS FROM THE TESTING OF 311 CHEMICALS

被引：327

作者：

ZEIGER, E

ANDERSON, B

HAWORTH, S

LAWLOR, T

MORTELMANS, K

机构：

[1] MICROBIOL ASSOCIATES INC,DEPT GENET TOXICOL,ROCKVILLE,MD

[2] SRI INT,DEPT MICROBIAL GENET,MENLO PK,CA 94025

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1992年 / 19卷

关键词：

AMES TEST; NATIONAL TOXICOLOGY PROGRAM; MUTAGENICITY TESTING; SALMONELLA;

D O I：

10.1002/em.2850190603

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. Some of the volatile chemicals were also tested in desiccators. A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic. The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested. The results and data from these tests are presented.

引用

页码：2 / 141

页数：140

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