Rate of Conversion from Prodromal Alzheimer's Disease to Alzheimer's Dementia: A Systematic Review of the Literature

被引：325
作者：
Ward, Alex [1 ]
Tardiff, Sarah [1 ]
Dye, Catherine [1 ]
Arrighi, H. Michael [2 ]
机构：
[1] United BioSource Corp, Lexington, MA USA
[2] Janssen Alzheimer Immunotherapy Res & Dev LLC, San Francisco, CA 94132 USA
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2013年 / 3卷 / 01期
关键词：
Cognitive function; Alzheimer's dementia; Alzheimer's disease; Meta-analysis; Mild cognitive impairment;
D O I：
10.1159/000354370
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The purpose of this study was to summarize published estimates for conversion from mild cognitive impairment or amnestic mild cognitive impairment to Alzheimer's dementia. We carried out a systematic review of English language publications to identify cohort studies published since January 2006 that reported the risk or rate of conversion. Summary: Thirty-two cohort studies were identified, of which 14 reported annualized conversion rates (ACRs). Conversions over 1 year ranged from 10.2 to 33.6% (5 studies, median: 19.0%), and over 2 years from 9.8 to 36.3% (7 studies, median: 18.6%). ACRs ranged from 7.5 to 16.5% (7 studies, median: 11.0%) per person-year for studies recruiting from clinics, and from 5.4 to 11.5% (7 studies, median: 7.1%) for community samples. Key Message: Extensive variation was observed in conversion rates due to the population sampled, diagnostic criteria, and duration, and because many studies did not account for loss to follow-up. (C) 2013 S. Karger AG, Basel
引用
收藏
页码：320 / 332
页数：13
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