Carcinoma cells reprogram a wound-healing switch to promote metastasis

被引：1
作者：
Sundaram, Gopinath M. [1 ]
Sampath, Prabha [1 ,2 ,3 ]
机构：
[1] ASTAR, Inst Med Biol, 8A Biomed Grove,05-41 Immunos, Singapore 138648, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore
[3] Duke NUS Med Sch, Program Canc & Stem Cell Biol, 8 Coll Rd, Singapore, Singapore
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 06期
基金：
英国医学研究理事会;
关键词：
microRNA; EGF; cancer; molecular switch; biology of malignant cells and metastasis;
D O I：
10.1080/23723556.2018.1432255
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Wound healing is a dynamic event where barrier disruption is transient and miR-198/FSTL1 molecular switch orchestrate wound re-epithelialization. However, epithelial carcinomas maintain a prolonged wound-healing phase to promote malignant transformation. Delineating the molecular mechanism we demonstrate, how epidermal growth factor (EGF) hijacks the wound-healing switch to promote metastasis of carcinoma.
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页数：2
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  • [1] Inhibitory signalling to the Arp2/3 complex steers cell migration
    Dang, Irene
    Gorelik, Roman
    Sousa-Blin, Carla
    Derivery, Emmanuel
    Guerin, Christophe
    Linkner, Joern
    Nemethova, Maria
    Dumortier, Julien G.
    Giger, Florence A.
    Chipysheva, Tamara A.
    Ermilova, Valeria D.
    Vacher, Sophie
    Campanacci, Valerie
    Herrada, Isaline
    Planson, Anne-Gaelle
    Fetics, Susan
    Henriot, Veronique
    David, Violaine
    Oguievetskaia, Ksenia
    Lakisic, Goran
    Pierre, Fabienne
    Steffen, Anika
    Boyreau, Adeline
    Peyrieras, Nadine
    Rottner, Klemens
    Zinn-Justin, Sophie
    Cherfils, Jacqueline
    Bieche, Ivan
    Alexandrova, Antonina Y.
    David, Nicolas B.
    Small, J. Victor
    Faix, Jan
    Blanchoin, Laurent
    Gautreau, Alexis
    [J]. NATURE, 2013, 503 (7475) : 281 - +
  • [2] Tumors: Wounds That Do Not Heal-Redux
    Dvorak, Harold F.
    [J]. CANCER IMMUNOLOGY RESEARCH, 2015, 3 (01) : 1 - 11
  • [3] Collective cell migration: Implications for wound healing and cancer invasion
    Li, Li
    He, Yong
    Zhao, Min
    Jiang, Jianxin
    [J]. BURNS & TRAUMA, 2013, 1 : 21 - 26
  • [4] Anti-EGFR Therapy: Strategies in Head and Neck Squamous Cell Carcinoma
    Oliveira-Silva, Renato J.
    de Carvalho, Ana Carolina
    Viana, Luciano de Souza
    Carvalho, Andre L.
    Reis, Rui M.
    [J]. RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2016, 11 (02) : 170 - 183
  • [5] Expression of matrix metalloproteinase-9 in head and neck squamous cell carcinoma:: A potential marker for prognosis
    Ruokolainen, H
    Pääkkö, P
    Turpeenniemi-Hujanen, T
    [J]. CLINICAL CANCER RESEARCH, 2004, 10 (09) : 3110 - 3116
  • [6] EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis
    Sundaram, Gopinath M.
    Ismail, Hisyam M.
    Bashir, Mohsin
    Muhuri, Manish
    Vaz, Candida
    Nama, Srikanth
    Ow, Ghim Siong
    Vladimirovna, Ivshina Anna
    Ramalingam, Rajkumar
    Burke, Brian
    Tanavde, Vivek
    Kuznetsov, Vladimir
    Lane, E. Birgitte
    Sampath, Prabha
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (10) : 2889 - 2900
  • [7] 'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing
    Sundaram, Gopinath M.
    Common, John E. A.
    Gopal, Felicia E.
    Srikanta, Satyanarayana
    Lakshman, Krishnaswamy
    Lunny, Declan P.
    Lim, Thiam C.
    Tanavde, Vivek
    Lane, E. Birgitte
    Sampath, Prabha
    [J]. NATURE, 2013, 495 (7439) : 103 - 106
  • [8] The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
    Trabucchi, Michele
    Briata, Paola
    Garcia-Mayoral, MariaFlor
    Haase, Astrid D.
    Filipowicz, Witold
    Ramos, Andres
    Gherzi, Roberto
    Rosenfeld, Michael G.
    [J]. NATURE, 2009, 459 (7249) : 1010 - U144
  • [9] TGFβ signaling in head and neck squamous cell carcinoma
    White, R. A.
    Malkoski, S. P.
    Wang, X-J
    [J]. ONCOGENE, 2010, 29 (40) : 5437 - 5446
  • [10] Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
    Winn, RA
    Marek, L
    Han, SY
    Rodriguez, K
    Rodriguez, N
    Hammond, M
    Van Scoyk, M
    Acosta, H
    Mirus, J
    Barry, N
    Bren-Mattison, Y
    Van Raay, TJ
    Nemenoff, RA
    Heasley, LE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) : 19625 - 19634
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