SYNERGISTIC EFFECTS OF TRAUMATIC HEAD-INJURY AND APOLIPOPROTEIN-EPSILON-4 IN PATIENTS WITH ALZHEIMERS-DISEASE

被引：476
作者：
MAYEUX, R
OTTMAN, R
MAESTRE, G
NGAI, C
TANG, MX
GINSBERG, H
CHUN, M
TYCKO, B
SHELANSKI, M
机构：
[1] COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL,NEW YORK,NY 10032
[2] COLUMBIA UNIV,CTR ALZHEIMERS DIS RES,NEW YORK,NY 10032
[3] COLUMBIA UNIV,DEPT NEUROL,NEW YORK,NY 10032
[4] COLUMBIA UNIV,DEPT PSYCHIAT,NEW YORK,NY 10032
[5] COLUMBIA UNIV,DEPT PATHOL,NEW YORK,NY 10032
[6] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032
[7] NEW YORK STATE PSYCHIAT INST & HOSP,EPIDEMIOL BRAIN DISORDERS RES DEPT,NEW YORK,NY
来源：
NEUROLOGY | 1995年 / 45卷 / 03期
关键词：
D O I：
10.1212/WNL.45.3.555
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The apolipoprotein-epsilon 4 allele increases the risk of Alzheimer's disease (AD), but cerebral deposition of beta-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein-epsilon 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein-epsilon 4 and a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein-epsilon 4 alone. Head injury in the absence of an apolipoprotein-epsilon 4 allele did not increase risk. These data imply that the biological effects of head injury may increase the risk of AD, but only through a synergistic relationship with apolipoprotein-epsilon 4.
引用
收藏
页码：555 / 557
页数：3
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