INTERACTION OF PEPTIDES DERIVED FROM THE FAS LIGAND WITH THE FYN-SH3 DOMAIN

被引：45

作者：

HANE, M

LOWIN, B

PEITSCH, M

BECKER, K

TSCHOPP, J

机构：

[1] UNIV LAUSANNE, INST BIOCHEM, CH-1066 EPALINGES, SWITZERLAND

[2] GLAXO INST MOLEC BIOL, CH-1028 PLAN LES OUATES, SWITZERLAND

来源：

FEBS LETTERS | 1995年 / 373卷 / 03期

关键词：

FYN; SH3; DOMAIN; FAS LIGAND; APO-1; APOPTOSIS;

D O I：

10.1016/0014-5793(95)01051-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interaction of the widely expressed Pas with its membrane-bound ligand (Fast) leads to rapid cell death via apoptosis. To avoid pathological tissue damage, the activity of Fast requires tight regulation, Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of Fast, Binding of the SH3 domain occurs between amino acid residues 44-71 which contains several potential SH3 interaction sites, This binding is specific, as SH3 domains of Lck, Grb2 and ras-GAP bind only weakly or not at all. We suggest that Fast activity may be modulated by SH3 domains of the src-like Fyn kinase.

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页码：265 / 268

页数：4

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