INTERACTION OF PEPTIDES DERIVED FROM THE FAS LIGAND WITH THE FYN-SH3 DOMAIN

被引：45
作者：
HANE, M
LOWIN, B
PEITSCH, M
BECKER, K
TSCHOPP, J
机构：
[1] UNIV LAUSANNE, INST BIOCHEM, CH-1066 EPALINGES, SWITZERLAND
[2] GLAXO INST MOLEC BIOL, CH-1028 PLAN LES OUATES, SWITZERLAND
来源：
FEBS LETTERS | 1995年 / 373卷 / 03期
关键词：
FYN; SH3; DOMAIN; FAS LIGAND; APO-1; APOPTOSIS;
D O I：
10.1016/0014-5793(95)01051-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interaction of the widely expressed Pas with its membrane-bound ligand (Fast) leads to rapid cell death via apoptosis. To avoid pathological tissue damage, the activity of Fast requires tight regulation, Here, we report that the Src homology 3 (SH3) domain of Fyn binds to the proline-rich cytoplasmic region of Fast, Binding of the SH3 domain occurs between amino acid residues 44-71 which contains several potential SH3 interaction sites, This binding is specific, as SH3 domains of Lck, Grb2 and ras-GAP bind only weakly or not at all. We suggest that Fast activity may be modulated by SH3 domains of the src-like Fyn kinase.
引用
收藏
页码：265 / 268
页数：4
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