EFFECTS OF TREATMENT WITH SIMVASTATIN AND PRAVASTATIN ON COGNITIVE FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA

被引：41

作者：

CUTLER, N

SRAMEK, J

VEROFF, A

BLOCK, G

STAUFFER, L

LINES, C

机构：

[1] CALIF CLIN TRIALS,BEVERLY HILLS,CA 90211

[2] MERCK SHARP & DOHME LTD,RES LABS,BLUE BELL,PA 19422

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 39卷 / 03期

关键词：

SIMVASTATIN; PRAVASTATIN; CHOLESTEROL; COGNITIVE FUNCTION;

D O I：

10.1111/j.1365-2125.1995.tb04458.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day(-1)) and pravastatin (40 mg day(-1)) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.

引用

页码：333 / 336

页数：4

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