ANGIOTENSINS INDUCE THE RELEASE OF PROSTACYCLIN FROM RABBIT VAS-DEFERENS - EVIDENCE FOR RECEPTOR HETEROGENEITY

被引：14
作者：
CATALIOTO, RM
RENZETTI, AR
CRISCUOLI, M
MIZRAHI, J
SUBISSI, A
机构：
[1] Department of Pharmacology, Laboratori Guidotti S.p.A.2 2 Company related to 'lsA. Menarini-Pharmaceuticals', Florence, San Piero a Grado, 56122 Pisa, Italy.
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 256卷 / 01期
关键词：
ANGIOTENSIN; VAS DEFERENS; PROSTACYCLIN; ANGIOTENSIN AT(1) RECEPTOR; (RABBIT);
D O I：
10.1016/0014-2999(94)90621-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Angiotensin II and angiotensin III stimulated prostacyclin release in a time- and dose-dependent manner in both the prostatic and the non-prostatic part of the rabbit vas deferens. Also, angiotensin I enhanced the production of prostacyclin and its effect was blocked by captopril. Losartan, a type 1 (angiotensin AT(1))-selective receptor antagonist, prevented the angiotensin II-induced prostacyclin release. The agonist peptide, p-aminophenylalanine(6) angiotensin II, and the type 2 (angiotensin AT(2))-selective receptor antagonist, PD123319, were found active only in the prostatic portion, suggesting heterogeneity of the receptor population. In conclusion, an angiotensin AT(1) receptor mostly mediates the angiotensin-induced release of prostacyclin in the rabbit vas deferens.
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收藏
页码：93 / 97
页数：5
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