FACILE SYNTHESIS OF (+/-)-GALANTHAMINE AND (-)-GALANTHAMINE

被引：37
作者：
SZEWCZYK, J
WILSON, JW
LEWIN, AH
CARROLL, FI
机构：
[1] Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina, 27709
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 01期
关键词：
D O I：
10.1002/jhet.5570320132
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Amarylidacea alkaloid galanthamine (1a) is an acetylcholinesterase inhibitor that has been evaluated as a potential agent for the treatment of Alzheimer's disease. We report a very efficient synthesis of (+/-)-galanthamine [(+/-)-1a] from readily available isovanillin and tyramine. We have separated racemic galanthamine into its diastereoisomeric (1S)-camphanate esters and obtained both natural (-)- and unnatural (+)-galanthamine by lithium aluminum hydride removal of the acyl group.
引用
收藏
页码：195 / 199
页数：5
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