ASSESSMENT OF ANTI-HIV ACTIVITY OF SOME BENZIMIDAZOLYLTHIAZOLES

被引：15
作者：
BADAWEY, EAM
HAZZAA, AA
RIDA, SM
FAHMY, HTY
机构：
[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria
来源：
ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 09期
关键词：
D O I：
10.1002/ardp.19923250908
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Benzimidazolylthiazoles 2 were synthesized by condensing 1H-Benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human HIV, however, no significant activity was observed with any of these compounds.
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页码：565 / 567
页数：3
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