IDENTIFICATION OF A TRANSCRIPTIONAL ENHANCER ELEMENT UPSTREAM FROM THE PROTO-ONCOGENE FOS

被引：150
|
作者：
DESCHAMPS, J
MEIJLINK, F
VERMA, IM
机构：
来源：
SCIENCE | 1985年 / 230卷 / 4730期
关键词：
D O I：
10.1126/science.3865371
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Sequences upstream from the proto-ongogene fos were shown to be essential for its transcription. Transient expression of the chloramphenicol acetyltransferase (CAT) gene linked to upstream sequences of the fos gene including its promoter reveals that sequences located 64 to 404 base pairs 5'' to the fos cap site contain a typical transcriptional enhancer. Moreover, these enhancer sequences, which are strikingly conserved between mouse and human fos genes, coincide with a deoxyribonuclease I-hypersensitive site in the chromatin. The expression of the fos-CAT fusion genes was stimulated only two to three times by the fos inducer 12-0-tetradecanoyl phorbol-13-acetate. The fos enhancer does not appear to be tissue-specific.
引用
收藏
页码：1174 / 1177
页数：4
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