GENOTOXICITY OF BERYLLIUM, GALLIUM AND ANTIMONY IN SHORT-TERM ASSAYS

被引：86

作者：

KURODA, K ^{[1
]}

ENDO, G ^{[1
]}

OKAMOTO, A ^{[1
]}

YOO, YS ^{[1
]}

HORIGUCHI, S ^{[1
]}

机构：

[1] OSAKA CITY UNIV,SCH MED,ABENO KU,OSAKA 545,JAPAN

来源：

MUTATION RESEARCH | 1991年 / 264卷 / 04期

关键词：

REC ASSAY; SCE; BERYLLIUM; GALLIUM; ANTIMONY;

D O I：

10.1016/0165-7992(91)90072-C

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxicity of beryllium, gallium and antimony compounds was studied with the rec, Salmonella mutagenicity and SCE assays. In the rec assay, all the salts of the metals, BeCl2, Be(NO3)2, GaCl3, Ga(NO3)3, SbCl3, SbCl5, and an oxide, Sb2O3, had DNA-damaging activity. None of the compounds was mutagenic to Salmonella. In the SCE assays using V79 cells, 2 antimony(III) compounds, SbCl3 and Sb2O3, and 2 beryllium compounds, BeCl2 and Be(NO3)2, induced SCEs significantly. Sb2O3, slightly soluble in water, was positive in both the rec assay and the SCE assay at very low doses.

引用

页码：163 / 170

页数：8

共 18 条

[1] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS
AMES, BN
LEE, FD
DURSTON, WE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) : 782 - 786
[2] STUDIES ON THE GENOTOXICITY OF BERYLLIUM SULFATE INVITRO AND INVIVO
ASHBY, J
ISHIDATE, M
STONER, GD
MORGAN, MA
RATPAN, F
CALLANDER, RD
[J]. MUTATION RESEARCH, 1990, 240 (03): : 217 - 225
[3] Kada T., 1980, CHEM MUTAGENS, VVolume 6, P149
[4] REC ASSAY AND MUTAGENICITY STUDIES ON METAL-COMPOUNDS
KANEMATSU, N
HARA, M
KADA, T
[J]. MUTATION RESEARCH, 1980, 77 (02): : 109 - 116
[5] KURODA K, 1985, J JAPAN SOC AIR POLL, V20, P342
[6] INDUCTION BY INORGANIC METAL-SALTS OF SISTER CHROMATID EXCHANGES AND CHROMOSOME-ABERRATIONS IN HUMAN AND SYRIAN-HAMSTER CELL STRAINS
LARRAMENDY, ML
POPESCU, NC
DIPAOLO, JA
[J]. ENVIRONMENTAL MUTAGENESIS, 1981, 3 (06): : 597 - 606
[7] SISTER-CHROMATID EXCHANGES - A REPORT OF THE GENE-TOX PROGRAM
LATT, SA
ALLEN, J
BLOOM, SE
CARRANO, A
FALKE, E
KRAM, D
SCHNEIDER, E
SCHRECK, R
TICE, R
WHITFIELD, B
WOLFF, S
[J]. MUTATION RESEARCH, 1981, 87 (01): : 17 - 62
[8] MUTAGENICITY, CARCINOGENICITY AND TERATOGENICITY OF BERYLLIUM
LEONARD, A
LAUWERYS, R
[J]. MUTATION RESEARCH, 1987, 186 (01): : 35 - 42
[9] MARON DM, 1983, MUTAT RES, V54, P139
[10] STUDY OF THE MUTAGENICITY OF METAL DERIVATIVES WITH SALMONELLA-TYPHIMURIUM-TA102
MARZIN, DR
PHI, HV
[J]. MUTATION RESEARCH, 1985, 155 (1-2): : 49 - 51

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