INHIBITION OF POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS BY FLUORINATED NITROBENZENES

被引：5
|
作者：
ELFERINK, JGR [1 ]
DEIERKAUF, M [1 ]
机构：
[1] UNIV LEIDEN, SYLVIUS LABS, MED BIOCHEM LAB, WASSENAARSEWEG 72, 2333 AL LEIDEN, NETHERLANDS
来源：
CHEMICO-BIOLOGICAL INTERACTIONS | 1984年 / 52卷 / 02期
关键词：
D O I：
10.1016/0009-2797(84)90070-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The bifunctional fluorinated nitrobenzenes, 1,5-difluoro-2,4-dinitrobenzene (DFDNB) and 4,4''-difluoro-3,3''-dinitrodiphenyl sulfone (DFDNDPS), and the monofunctional 1-fluoro-2,4-dinitrobenzene (FDNB) inhibited chemotaxis, phagocytosis, exocytosis and the respiratory burst of rabbit polymorphonuclear leukocytes. Inhibition occurred in the micromolar concentration range; the bifunctional compounds showed stronger inhibition than the monofunctional one. The inhibitory effect was counteracted by SH compounds but not with amino-group containing compounds. The results suggested that an interaction with vulnerable SH groups, located in a hydrophobic surrounding, was the basis of the inhibitory effect of the fluorinated nitrobenzenes.
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页码：163 / 172
页数：10
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