2-BROMOETHYL GLYCOSIDES .6. SYNTHESIS FROM PULLULAN OF SPACER-ARM, LIPID, AND ETHYL GLYCOSIDES OF A TETRASACCHARIDE [ALPHA-D-GLC-(1-]6)-ALPHA-D-GLC-(1-]4)-ALPHA-D-GLC-(1-]4)-D-GLC] FOUND IN HUMAN-URINE - PREPARATION OF NEOGLYCOPROTEINS

被引：10
作者：
DAHMEN, J
FREJD, T
MAGNUSSON, G
NOORI, G
CARLSTROM, AS
机构：
来源：
CARBOHYDRATE RESEARCH | 1984年 / 127卷 / 01期
关键词：
D O I：
10.1016/0008-6215(84)85103-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enzymic hydrolysis of pullulan, followed by acetylation and chromatography, gave acetylated .alpha.-D-Glcp-(1 .fwdarw. 6)-.alpha.-D-Glcp-(1 .fwdarw. 4)-.alpha.-D-Glcp-(1 .fwdarw. 4)-D-Glcp which, with 2-bromoethanol and boron trifluoride etherate in dichloromethane, gave the 2-bromoethyl glycoside. The reactions of the glycoside with methyl 3-mercaptopropionate, methyl 11-mercaptoundecanoate and octadecanethiol as well as its hydrogenolysis to give an ethyl glycoside are described. The mercaptopropionate-derived, spacer-arm glycoside was coupled to bovine serum albumin and keyhole limpet hemocyanin.
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页码：27 / 33
页数：7
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