RIMCAZOLE (BW U-234), A NOVEL ANTIPSYCHOTIC AGENT WHOSE MECHANISM OF ACTION CANNOT BE EXPLAINED BY A DIRECT BLOCKADE OF POSTSYNAPTIC DOPAMINERGIC RECEPTORS IN BRAIN

被引：30
作者：
FERRIS, RM [1 ]
WHITE, HL [1 ]
TANG, FLM [1 ]
RUSSELL, A [1 ]
HARFENIST, M [1 ]
机构：
[1] WELLCOME RES LABS,DEPT ORGAN CHEM,RES TRIANGLE PK,NC 27709
来源：
DRUG DEVELOPMENT RESEARCH | 1986年 / 9卷 / 03期
关键词：
D O I：
10.1002/ddr.430090302
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：171 / 188
页数：18
相关论文
共 49 条
[1]   INDIVIDUAL ELUTION OF NORADRENALINE (TOGETHER WITH ADRENALINE), DOPAMINE, 5-HYDROXYTRYPTAMINE AND HISTAMINE FROM A SINGLE, STRONG CATION EXCHANGE COLUMN, BY MEANS OF MINERAL ACID-ORGANIC SOLVENT MIXTURES [J].
ATACK, CV ;
MAGNUSSO.T .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1970, 22 (08) :625-&
[2]   UTILIZATION OF SODIUM-DEPENDENT HIGH AFFINITY CHOLINE UPTAKE INVITRO AS A MEASURE OF ACTIVITY OF CHOLINERGIC NEURONS INVIVO [J].
ATWEH, S ;
SIMON, JR ;
KUHAR, MJ .
LIFE SCIENCES, 1975, 17 (10) :1535-1544
[3]  
BURNS RF, 1980, P NATL ACAD SCI US, V77, P554
[4]  
BURT DR, 1976, MOL PHARMACOL, V12, P800
[5]   ANTIPSYCHOTIC-DRUGS, NEUROTRANSMITTERS, AND SCHIZOPHRENIA [J].
CARLSSON, A .
AMERICAN JOURNAL OF PSYCHIATRY, 1978, 135 (02) :164-173
[6]  
CARLSSON A, 1978, PSYCHOPHARMACOLOGY G, P1057
[7]   BEHAVIORAL AND BIOCHEMICAL CONSEQUENCES OF PERSISTENT OVERSTIMULATION OF MESOLIMBIC DOPAMINE SYSTEMS IN THE RAT [J].
COSTALL, B ;
DOMENEY, AM ;
NAYLOR, RJ .
NEUROPHARMACOLOGY, 1982, 21 (04) :327-335
[8]  
DAVIDSON J, 1982, Psychopharmacology Bulletin, V18, P173
[9]   PROPERTIES OF GAMMA-AMINOBUTYRIC ACID (GABA) RECEPTOR-BINDING IN RAT-BRAIN SYNAPTIC MEMBRANE-FRACTIONS [J].
ENNA, SJ ;
SNYDER, SH .
BRAIN RESEARCH, 1975, 100 (01) :81-97
[10]   BW234U, (CIS-9-[3-(3,5-DIMETHYL-1-PIPERAZINYL)PROPYL]CARBAZOLE DIHYDROCHLORIDE) - A NOVEL ANTIPSYCHOTIC AGENT [J].
FERRIS, RM ;
HARFENIST, M ;
MCKENZIE, GM ;
COOPER, B ;
SOROKO, FE ;
MAXWELL, RA .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1982, 34 (06) :388-390
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