I-124-MIBG: a new promising positron-emitting radiopharmaceutical for the evaluation of neuroblastoma

被引：35

作者：

Cistaro, Angelina ^{[1
,2
,3
]}

Quartuccio, Natale ^{[4
]}

Caobelli, Federico ^{[5
]}

Piccardo, Arnoldo ^{[6
]}

Paratore, Rosario ^{[7
]}

Coppolino, Pietro ^{[4
]}

Sperandeo, Alessandro ^{[7
]}

Arnone, Gaspare ^{[8
]}

Ficola, Umberto ^{[7
]}

机构：

[1] Euromedic Inc, Positron Emiss Tomog Ctr IRMET SpA, VO Vigliani 89-A, I-10138 Turin, Italy

[2] PET Pediat AIMN InterGrp, Turin, Italy

[3] CNR, Inst Cognit Sci & Technol, Rome, Italy

[4] Univ Messina, Dept Biomed Sci & Morphol & Funct Images, Nucl Med Unit, Messina, Italy

[5] Hannover Med Sch, Nucl Med Unit, Hannover, Germany

[6] Galliera Hosp, Nucl Med Unit, Genoa, Italy

[7] La Maddalena Hosp, Dept Nucl Med, Palermo, Italy

[8] Civ Hosp, Nucl Med Operating Unit, Palermo, Italy

来源：

NUCLEAR MEDICINE REVIEW | 2015年 / 18卷 / 02期

关键词：

neuroblastoma; I-124-MIBG PET/CT; bone metastases; I-123-MIBG scan; radiometabolic therapy;

D O I：

10.5603/NMR.2015.0024

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Neuroblastoma is the most common extra-cranial solid tumor in pediatric patients. Despite the established role of I-123-MIBG and I-131-MIBG scintigraphy in this tumor, only limited data are available regarding the use of I-124-metaiodobenzylguanidine (MIBG) positron emission tomography (PET)/computed tomography (CT). We present our preliminary experience with I-124-MIBG PET/CT: two pediatric patients affected by neuroblastoma, who underwent I-124-MIBG PET/CT for pre-therapy distribution evaluation and restaging purposes. We aimed to evaluate whether I-124-MIBG PET/CT can detect as many or more neuroblastoma lesions than I-123/I-131-MIBG imaging. Our cases show promising results, although further validation and standardization of I-124-MIBG PET/CT are required.

引用

页码：102 / 106

页数：5

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