REPEATED STRESS CAUSES REVERSIBLE IMPAIRMENTS OF SPATIAL MEMORY PERFORMANCE

被引：602

作者：

LUINE, V ^{[1
]}

VILLEGAS, M ^{[1
]}

MARTINEZ, C ^{[1
]}

MCEWEN, BS ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEUROENDOCRINOL LAB,NEW YORK,NY 10021

来源：

BRAIN RESEARCH | 1994年 / 639卷 / 01期

关键词：

SPATIAL MEMORY; RADIAL ARM MAZE; HIPPOCAMPUS; STRESS; TIANEPTINE; PHENYTOIN;

D O I：

10.1016/0006-8993(94)91778-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Restraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.

引用

页码：167 / 170

页数：4

共 18 条

[1] NEONATAL ANOXIA INDUCES TRANSITORY HYPERACTIVITY, PERMANENT SPATIAL MEMORY DEFICITS AND CA1 CELL-DENSITY REDUCTION IN DEVELOPING RATS [J].