SUBTRACT - A COMPUTER-PROGRAM FOR MODELING THE PROCESS OF SUBTRACTIVE HYBRIDIZATION

被引：0

作者：

ERMOLAEVA, OD ^{[1
]}

WAGNER, MC ^{[1
]}

机构：

[1] LAWRENCE LIVERMORE NATL LAB,CTR HUMAN GENOME,LIVERMORE,CA 94550

来源：

COMPUTER APPLICATIONS IN THE BIOSCIENCES | 1995年 / 11卷 / 04期

关键词：

D O I：

暂无

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

We report on a new software tool, SUBTRACT, which allows the analysis of the possible strategies for an experiment based on a mathematical model of subtractive hybridization. The program helps the experimenter choose the optimal strategy and conditions for performing the reaction. The program allows the modeling of cDNA and genomic subtraction for different types of target DNA. SUBTRACT offers a friendly interface for the investigation of the dynamics of the process of subtractive hybridization, and for modifying different parameters and initial conditions. SUBTRACT allows the user to plot the values of interesting quantities as a function of the reaction time. The program runs under the Unix operating system on Sun-compatible computers.

引用

页码：457 / 461

页数：5

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