A BRITISH-NATIONAL-LYMPHOMA-INVESTIGATION RANDOMIZED TRIAL OF SINGLE-AGENT CHLORAMBUCIL PLUS RADIOTHERAPY VERSUS RADIOTHERAPY ALONE IN LOW-GRADE, LOCALIZED NON-HODGKINS-LYMPHOMA

被引：61

作者：

KELSEY, SM ^{[1
]}

NEWLAND, AC ^{[1
]}

HUDSON, GV ^{[1
]}

JELLIFFE, AM ^{[1
]}

机构：

[1] ROYAL LONDON HOSP,DEPT HAEMATOL,LONDON,ENGLAND

来源：

MEDICAL ONCOLOGY | 1994年 / 11卷 / 01期

关键词：

CHLORAMBUCIL; RADIOTHERAPY; LOW-GRADE NON-HODGKINS LYMPHOMA;

D O I：

10.1007/BF02990087

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Local radiotherapy (RT) alone was compared with radiotherapy plus continuous oral chlorambucil (RT + CHL) for the treatment of localised, low grade non-Hodgkins lymphoma (NHL) in a prospective randomised study of 148 patients. After a maximum of 18 years follow up there was no significant difference in overall survival or disease free survival between the two treatment groups. Age greater than 50 years and low serum albumin at diagnosis correlated with a poor prognosis in the series overall. Over one third of patients with localised, low grade NHL may be cured by RT alone and adjuvant chlorambucil as initial therapy confers no survival advantage.

引用

页码：19 / 25

页数：7

共 21 条

[1]

Phillips D.L, Radiotherapy in the treatment of localised nonHodgkins lymphomas, Clinical Radiology, 32, pp. 543-546, (1981)

[2]

Goffinet D.R, Warnke R., Dunnick N.R, Et al., Clinical and surgical (laparotomy) evaltaation of patients with nonHodgkins lymphoma, Cancer Treatment Reports, 61, pp. 981-992, (1977)

[3]

Chabner B.A, Johnson R.E, Young R.C, Sequential non-surgical and surgical staging of nonHodgkins lymphoma, Ann Intern Med, 85, pp. 149-154, (1976)

[4]

Lister T.A, The management of follicular lymphoma, Annals of Ontology, 2, 2, pp. 131-135, (1991)

[5]

Richards M., Gregory W.M, Hall P.A, Et al., Management of localised nonHodgkins lymphoma: the experience at St. Bartholemews hospital 1972-1985, Haematological Oncology, 7, (1989)

[6]

McLaughlin P., Fuller L.M, Velasquez M.S, Et al., Stage III follicular lymphoma: treatment results for 76 patients, Cancer, 58, pp. 1596-1602, (1986)

[7]

Nissen N.I, Ersboll J., Hansen H.S, Et al., A randomised study of radiotherapy versus radiotherapy plus chemotherapy in stage III non-Hodgkins lymphoma, Cancer, 52, (1983)

[8]

Bennett M.H, FarrerBrown H.K, Jelliffe A.M, Classification of nonHodgkins lymphomas, Lancet, 2, pp. 405-406, (1974)

[9]

Peto R., Pike M.C, Armitage P., Breslow N.E, Cox D.R, Howard S.V, Mantel N., McPherson K., Peto J., Smith P., Design and analysis of randomised clinical trials requiring prolonged observation of each patient. II. Analysis and examples, British Journal of Cancer, 35, (1977)

[10]

Cox D.R, Regression models and life tables, Journal of the Royal Statistical Society (series B), 34, pp. 187-220, (1972)

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