FREE-RADICALS AND PHAGOCYTIC-CELLS

被引:380
作者
ROSEN, GM
POU, S
RAMOS, CL
COHEN, MS
BRITIGAN, BE
机构
[1] VET AFFAIRS MED CTR,RES SERV,BALTIMORE,MD 21201
[2] UNIV N CAROLINA,DEPT MED,CHAPEL HILL,NC 27599
[3] UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599
[4] VET AFFAIRS MED CTR,RES SERV,IOWA CITY,IA 52246
[5] VET AFFAIRS MED CTR,DEPT INTERNAL MED,IOWA CITY,IA 52246
[6] UNIV IOWA,COLL MED,DEPT INTERNAL MED,IOWA CITY,IA 52242
关键词
SUPEROXIDE; HYDROXYL RADICAL; NEUTROPHIL; NITRIC OXIDE;
D O I
10.1096/fasebj.9.2.7540156
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phagocytes mediate their innate immunological response by releasing products that damage invading microorganisms. These products include proteins such as lysozyme, peroxidases, and elastase as well as reactive oxygen species such as superoxide, hydrogen peroxide, hypohalous acid, and hydroxyl radical. Although it is clear that many phagocytic secretory products have direct cytotoxic potential, understanding is limited of how multiple products interact to generate and modulate the cytotoxic response. This review focuses on recent findings that elucidate the biochemical nature of secretory product interaction in the formation of free radicals, particularly the highly reactive hydroxyl radical. The possible role of these reactions in phagocyte microbicidal activity and inflammatory tissue injury is discussed.
引用
收藏
页码:200 / 209
页数:10
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