CAPSAICIN - ACTIONS ON NOCICEPTIVE C-FIBERS AND THERAPEUTIC POTENTIAL

被引：216

作者：

LYNN, B

机构：

[1] Department of Physiology, University College London

来源：

PAIN | 1990年 / 41卷 / 01期

关键词：

C-fibre; Capsaicin; Pain; Polymodal nociceptor; Post-herpetic neuralgia;

D O I：

10.1016/0304-3959(90)91110-5

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Recent work on the excitatory action of capsaicin on somatic and visceral afferent neurones shows that depolarization is selective for C-fibre polymodal nociceptor afferents and involves opening a non-selective cation channel. Exposure to significantly suprathreshold amounts of capsaicin causes permanent degeneration of C-fibre afferents in adult rats. Functional changes in rats (hypalgesia, diminished neurogenic inflammation) are likely to be a direct consequence of the loss of C-fibre nociceptors and so are the reductions in neuropeptide levels that follow adult capsaicin treatment. Clinical trials of topical capsaicin treatment for post-herpetic neuralgia have yielded promising results. The selective nature of the action of capsaicin in reducing just C-nociceptor activity may make it particularly useful for treating pain states triggered by C-fibre input. © 1990.

引用

页码：61 / 69

页数：9

共 84 条

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