OPTIMIZING THE PRODUCTION OF RECOMBINANT PROTEINS IN MICROORGANISMS

被引：77
作者：
GEORGIOU, G
机构：
[1] Univ of Texas, Austin, TX, USA, Univ of Texas, Austin, TX, USA
来源：
AICHE JOURNAL | 1988年 / 34卷 / 08期
关键词：
GENE AMPLIFICATION - HOST ORGANISM - PLASMID STABILITY;
D O I：
10.1002/aic.690340802
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
To optimize the production of recombinant proteins, the special characteristics and physiology of genetically-engineered cells must be taken into account in the design of optimal bioreactors. The scale-up of processes involving recombinant organisms is currently one of the central problems in biochemical engineering. Related research is being conducted in cellular physiology, fermentations, reactor design, mathematical modelling, instrumentation, and product recovery. 162 Refs.
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页码：1233 / 1248
页数：16
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