DETERMINATION OF BENZBROMARONE AND BENZARONE IN PHARMACEUTICALS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：1

作者：

GUMIENICZEK, A

PRZYBOROWSKI, L

机构：

[1] Department of Medicinal Chemistry, Medical Academy, 20-093 Lublin

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 16期

关键词：

D O I：

10.1080/10826079408013521

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Assay procedure based on high-performance liquid chromatography has been developed for the Specific determination of benzbromarone and benzarone in pharmaceutical dosage forms, using a LiChrosorb RP-18 column, a mobile phase acetonitrile-phosphate buffer pH 2,6 (9:1 v/v) and UV detection at 240 nm. Benzbromarone and benzarone have been extracted from tablets with methanol and determined in the range 2-12 mu g/ml with fairly good recovery (mean 99,63% and 99,78% for benzbromarone and benzarone, respectively) and reproducibility.

引用

页码：3411 / 3419

页数：9

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