NOREPINEPHRINE TRANSPORTER MESSENGER-RNA IS ELEVATED IN THE LOCUS-CERULEUS FOLLOWING SHORT-TERM AND LONG-TERM DESIPRAMINE TREATMENT

被引：53

作者：

SZOT, P

ASHLIEGH, EA

KOHEN, R

PETRIE, E

DORSA, DM

VEITH, R

机构：

[1] UNIV WASHINGTON,DEPT PSYCHIAT & BEHAV SCI,SEATTLE,WA 98195

[2] UNIV WASHINGTON,DEPT PHARMACOL,SEATTLE,WA 98195

来源：

BRAIN RESEARCH | 1993年 / 618卷 / 02期

关键词：

TRICYCLIC ANTIDEPRESSANT; DESIPRAMINE; NOREPINEPHRINE TRANSPORTER MESSENGER-RNA; LOCUS-CERULEUS; TRANSPORTER;

D O I：

10.1016/0006-8993(93)91281-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In situ hybridization for the norepinephrine transporter (NET) MRNA was performed in animals receiving short-term (2 days) and long-term (4 weeks) treatment with desipramine (DMI; 10 mg/kg, intraperitoneal). Following short-term and long-term DMI treatment, a significant (P < 0.05) increase in hybridization of S-35-labeled oligonucleotides to NET mRNA in the locus coeruleus was observed compared to that observed in vehicle-treated animals. The mechanism of this increase in transporter mRNA or its involvement in the therapeutic effects of anti-depressants remains to be determined.

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页码：308 / 312

页数：5

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