GLUTAMATE AS A NEURON-TO-GLIAL SIGNAL FOR MITOGENESIS - ROLE OF GLIAL N-METHYL-D-ASPARTATE RECEPTORS

被引：75
作者：
UCHIHORI, Y
PURO, DG
机构：
[1] UNIV MICHIGAN,WK KELLOGG EYE CTR,DEPT OPHTHALMOL,1000 WALL ST,ANN ARBOR,MI 48105
[2] UNIV MICHIGAN,DEPT PHYSIOL,ANN ARBOR,MI 48105
来源：
BRAIN RESEARCH | 1993年 / 613卷 / 02期
关键词：
MULLER CELL; GLIA; RETINA; PROLIFERATION; N-METHYL-D-ASPARTATE RECEPTOR CHANNEL; GLUTAMATE;
D O I：
10.1016/0006-8993(93)90901-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The presence on glial cells of receptors for neurotransmitters suggests the capability of neuron-to-glial signalling. Here, we asked whether the retinal transmitter, glutamate, may serve as a mitogenic signal for human retinal glial cells. Using cultured glia from the adult postmortem retina, we found that glutamate stimulated the proliferation of these glial cells. Pharmacological experiments indicated that this proliferative effect involved activation of N-methyl-D-aspartate (NMDA) receptor channels. Activation of NMDA receptors on retinal glial cells may mediate a proliferative response of these cells to pathophysiologic conditions causing a sustained elevation of glutamate.
引用
收藏
页码：212 / 220
页数：9
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