3,400 NEW EXPRESSED SEQUENCE TAGS IDENTIFY DIVERSITY OF TRANSCRIPTS IN HUMAN BRAIN

被引：298

作者：

ADAMS, MD ^{[1
]}

KERLAVAGE, AR ^{[1
]}

FIELDS, C ^{[1
]}

VENTER, JC ^{[1
]}

机构：

[1] NINCDS,RECEPTOR BIOCHEM & MOLECU BIOL SECT,BETHESDA,MD 20892

来源：

NATURE GENETICS | 1993年 / 4卷 / 03期

关键词：

D O I：

10.1038/ng0793-256

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We present the results of the partial sequencing of over 3,400 expressed sequence tags (ESTs) from human brain cDNA clones, which increases the number of distinct genes expressed in the brain, that are represented by ESTs, to about 6,000. By choosing clones in an unbiased manner, it is possible to construct a profile of the transcriptional activity of the brain at different stages. Proteins that comprise the cytoskeleton are the most abundant; however, a large variety of regulatory proteins are also seen. About half of the ESTs predicted to contain a protein-coding region have no matches in the public peptide databases and may represent new gene families.

引用

页码：256 / 267

页数：12

共 30 条

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