Intussusception in Young Children: Protocol for Multisite Hospital Sentinel Surveillance in India

被引：7
作者：
Das, Manoja Kumar [1 ]
Arora, Narendra Kumar [1 ]
Bonhoeffer, Jan [2 ,3 ]
Zuber, Patrick L. F. [4 ]
Maure, Christine G. [4 ]
机构：
[1] INCLEN Trust Int, New Delhi 110020, India
[2] Univ Basel, Univ Childrens Hosp UKBB, CH-4056 Basel, Switzerland
[3] Brighton Collaborat Fdn, CH-4056 Basel, Switzerland
[4] WHO, Dept Essential Med & Hlth Prod, CH-1211 Geneva 27, Switzerland
来源：
METHODS AND PROTOCOLS | 2018年 / 1卷 / 02期
关键词：
intussusception; retrospective; prospective; surveillance; rotavirus vaccine;
D O I：
10.3390/mps1020011
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
India has recently introduced a rotavirus vaccine under a universal immunization program. There is limited information on intussusception, an adverse event, following immunization in children from India. We are conducting sentinel surveillance for intussusception in children aged under two years at 19 hospitals. The sentinel sites' selection followed a multistage process. The surveillance combines retrospective surveillance for 69 months and prospective surveillance for 18 months. The suspected intussusception cases shall be reviewed for capturing confirmed cases and detailed data collection and classification according to Brighton Collaboration criteria. Data shall be analysed to describe epidemiology, trends, regional and seasonal variations, clinical profiles, management modalities, and outcomes of intussusception. The combination of prospective and retrospective surveillance shall be informative about the trend of intussusception over the last seven years in India. At four sites where rotavirus vaccines have been introduced, the change in intussusception trends shall be documented. The potential association with rotavirus vaccines and other vaccines shall be assessed using case-control and self-controlled case series methodology. Results are forthcoming. The results shall support the national vaccine safety surveillance effort by providing baseline estimates of intussusception for continued monitoring. The surveillance protocol and site selection processes shall inform similar vaccine-safety surveillance in India and other developing countries.
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页码：1 / 9
页数：9
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