THEORETICAL APPROACH FOR LIGAND BASED DRUG DESIGN OF LPXC: A KEY ENZYME OF LIPID A BIOSYNTHESIS

被引：0

作者：

Sharma, Shyamal ^{[1
]}

Mondal, Uttam Kumar ^{[1
]}

Mukhopadhyay, Subhasis ^{[2
]}

Bothra, Asim Kumar ^{[1
]}

机构：

[1] Raiganj Coll Univ Coll, Dept Chem, Cheminformat Bioinformat Lab, Raiganj 733134, W Bengal, India

[2] Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Kolkata 700009, W Bengal, India

来源：

PHARMACOPHORE | 2014年 / 5卷 / 05期

关键词：

LpxC; Regression model; Docking; Hydrophobicity;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lipid A is an essential component of the outer membranes of the gram negative bacteria and genetic evidence has established that inhibition of its biosynthesis is lethal to gram-negative bacteria. It is seen that hydrophobicity is very important factor for the activity of LpxC inhibitors. Regression model developed in this work may be essential step for further development in designing and synthesis of good LpxC inhibitors.

引用

页码：657 / 675

页数：19

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